Manchester City vs Bayer Leverkusen: Predictions, Betting odds, Lineups, Preview

Explore Coral's detailed preview for Manchester City vs Bayer Leverkusen in the UEFA Champions League. Stats, odds, predictions, and lineups for the 20:00 GMT match.

• Fixture: Manchester City vs Bayer Leverkusen
• Date: Tuesday, 25 November 2025
• Kick-off: 20:00 GMT
• Venue: Etihad Stadium

Manchester City, coming off a strong run of form with three wins and a draw in their recent matches, are likely to dominate possession and create numerous scoring opportunities against Bayer Leverkusen. Their recent victories, including a convincing 4-1 win over Borussia Dortmund at home, suggest they are in good shape to exploit Leverkusen's defensive vulnerabilities, particularly after the German side's heavy 2-7 loss to Paris Saint-Germain.

Bayer Leverkusen, on the other hand, have shown inconsistency with a win, a loss, and two draws in their last four games. Their ability to grind out a 1-0 victory away at Benfica indicates they can be resilient, but their defensive frailties, as seen in the PSG match, might be exposed by Manchester City's attacking prowess. Leverkusen will need to be highly organised and possibly rely on counter-attacks to have a chance in this match.

Manchester City's recent form has been impressive, with three wins and a draw in their last four matches. Their ability to secure victories both at home and away, including a 4-1 thrashing of Borussia Dortmund and a 2-0 win against Villarreal, showcases their strength and consistency. This form suggests they are well-prepared to take on Bayer Leverkusen, with their attacking line likely to pose significant threats.

Recent UEFA Champions League Results:

• Win: 4-1 vs Borussia Dortmund (H)
• Win: 2-0 vs Villarreal (A)
• Draw: 2-2 vs Monaco (A)
• Win: 2-0 vs Napoli (H)

Bayer Leverkusen's recent performances have been mixed, with a win, a heavy loss, and two draws in their last four games. Their 1-0 victory against Benfica away from home shows they can be competitive, but the 2-7 defeat to Paris Saint-Germain at home highlights potential defensive issues. This inconsistency might make it challenging for them to contain Manchester City's potent attack.

Recent UEFA Champions League Results:

• Win: 1-0 vs Benfica (A)

• Loss: 2-7 vs Paris Saint-Germain (H)

• Draw: 1-1 vs PSV Eindhoven (H)

• Draw: 2-2 vs FC Copenhagen (A)

Manchester City and Bayer Leverkusen have never met in the Champions League. Instead of looking at the head-to-head, the game will have to be judged on the teams' recent performances and results. With Bayer missing so many players, City will be heavy favourites to win.

• Mateo Kovacic (Ankle) - Out

• Axel Tape (Hamstring) - Out

• Exequiel Palacios (Adductor) - Out

• Lucas Vázquez (Muscle) - Out

• Equi Fernandez (Ligament) - Out

• Arthur Augusto (Back) - Out

• Alejandro Grimaldo (Muscle) - Out

• Robert Andrich (Suspended) - Out

• Edmond Tapsoba (Suspended) - Out

• Nathan Tella (Knee) - Doubt

• Ernest Poku (Knock) - Doubt

• Predicted lineup: Donnarumma (GK), Nunes (DF), Dias (DF), Gvardiol (DF), O'Reilly (DF), Nico (MF), Cherki (MF), Silva (MF), Foden (MF), Doku (MF), Haaland (AT)

Manchester City's predicted lineup suggests a focus on maintaining possession and exploiting the talents of Cherki and Doku. At the same time, Haaland's presence up front will be crucial for converting chances into goals.

• Predicted lineup: Flekken (GK), Belocian (DF), Bade (DF), Quansah (DF), Tella (MF)(If fit), Maza (MF), Garcia (MF), Hofmann (MF), Kofane (AT), Poku (AT)(If fit), Schick (AT)

Bayer Leverkusen's predicted lineup suggests a reliance on a solid defensive structure, with Bade at the back, while Kofane and Schick will look to exploit any counter-attack opportunities.

• Doku vs Bade: This matchup will see Manchester City's dynamic attacker testing Bayer Leverkusen's central defender with his pace and dribbling skills.

• Foden vs Garcia: The battle in midfield between Manchester City's Foden and Bayer Leverkusen's Garcia will be crucial, with both players looking to control the tempo of the game.

• Nico (Manchester City): Nico is a key player for Manchester City due to his ability to anchor the midfield and distribute the ball effectively, providing a solid base for their attacking plays.

• Kofane (Bayer Leverkusen): Kofane is vital for Bayer Leverkusen as a forward, offering a threat in front of goal and the potential to lead their counter-attacks.

Manchester City vs Bayer Leverkusen at 20:00 GMT on Tuesday, 25 November 2025, will be broadcast live for viewers in the UK on TNT Sports 1 and TNT Sports Ultimate.

Coral is predicting that the score will be Manchester City 3-1 Bayer Leverkusen.

Coral is giving fans the ability to bet on various markets for Manchester City vs Bayer Leverkusen, including match betting, correct score and anytime scorer odds.

Coral brings you the most exciting offers to enhance your experience.

For the best UEFA Champions League outright predictions, explore our guide.

Odds and market details are accurate as of the time of publication.