Southampton vs Middlesbrough: Predictions, Betting odds, Lineups, Preview

Explore Coral's detailed preview for Southampton vs Middlesbrough in the Championship. Stats, odds, predictions, and lineups for the 15:00 BST match.

• Fixture: Southampton vs Middlesbrough

• Date: Saturday, 27 September 2025

• Kick-off: 15:00 BST

• Venue: St. Mary's Stadium

Match Prediction: Southampton 1-2 Middlesbrough

Southampton's recent form has been inconsistent, with three draws and two losses in their last five Championship matches. This suggests they struggle to find a winning rhythm against a Middlesbrough side that has been in good form, winning four out of their previous five league games. 

Southampton's play has been characterised by defensive lapses, as seen in their losses to Hull City and Stoke City, which Middlesbrough's attacking prowess could exploit.

Middlesbrough, on the other hand, have shown resilience and the ability to secure victories away from home, as demonstrated by their wins against Norwich City and Millwall. 

Their recent results indicate a team that is confident and capable of capitalising on Southampton's defensive vulnerabilities. The match could see Middlesbrough maintaining their momentum and challenging Southampton's backline throughout the game.

Southampton's recent form has been disappointing, with only one win in their last ten matches across all competitions. Their inability to secure victories, particularly at home, could impact their confidence going into this game. 

The draws against Portsmouth and Watford show a team that can hold its own but struggles to convert draws into wins. This inconsistency might lead to a cautious approach against a strong Middlesbrough side.

• Loss: 1-3 vs Hull City (A)

• Draw: 0-0 vs Portsmouth (H)

• Draw: 2-2 vs Watford (A)

• Loss: 1-2 vs Stoke City (H)

• Draw: 1-1 vs Ipswich Town (A)

Middlesbrough have been in excellent form, winning four out of their last five league encounters. This run of good results, including victories against strong teams like Sheffield United and West Bromwich Albion, suggests they are peaking at the right time.

Their ability to win away from home, as seen in their recent victories, could give them the edge in this match. Middlesbrough's confidence and attacking play could pose significant problems for Southampton's defence.

• Win: 2-1 vs West Bromwich Albion (H)

• Draw: 2-2 vs Preston North End (A)

• Win: 1-0 vs Sheffield United (H)

• Win: 2-1 vs Norwich City (A)

• Win: 3-0 vs Millwall (A)

The head-to-head record between Southampton and Middlesbrough shows a closely contested rivalry. In their most recent encounter, the teams drew 1-1, while Middlesbrough won the previous meeting.

Recent Championship Results

• Southampton 1-1 Middlesbrough (29 Mar 2024)

• Middlesbrough 2-1 Southampton (23 Sep 2023)

• Middlesbrough 2-1 Southampton (21 Apr 2012)

• Southampton 3-0 Middlesbrough (29 Oct 2011)

• Welington (Ankle) - Out

• Samuel Edozie (Knock) - Doubt

• Flynn Downes (Illness) - Doubt

• Riley McGree (Hamstring) - Out

• Dael Fry (Calf) - Out

• George Edmundson (Eye) - Out

• Seny Dieng (Achilles) - Out

• Alex Bangura (Hamstring) - Out

• Darragh Lenihan (Muscle) Doubt

• Predicted lineup: Bazunu, Roerslev, Harwood-Bellis, Stephens, Manning, Jander, Charles, Fellows, Azaz, Fraser, Armstrong

Southampton's predicted lineup suggests a focus on maintaining a solid defensive structure with Stephens and Harwood-Bellis at the back, while relying on the creativity of Azaz and Fraser to unlock Middlesbrough's defence.

• Predicted lineup: Brynn, Ayling, Lenihan (If fit), Jones, Brittain, Hackney, Morris, Targett, Conway, Nypan, Strelec

Middlesbrough's predicted lineup indicates a balanced approach, with Hackney and Morris providing stability in midfield, and the attacking threat of Conway and Strelec likely to test Southampton's defensive resolve.

• Roerslev vs Targett: This duel on the right flank could be crucial, with Roerslev's defensive duties tested by Targett's attacking runs.

• Manning vs Brittain: The battle between these two full-backs will be key, as both look to provide width and support their respective attacks.

• Fellows (Southampton): His ability to create chances from midfield could be vital for Southampton's hopes of securing a result.

• Conway (Middlesbrough): His recent form and goal-scoring threat make him a player to watch, especially against Southampton's vulnerable defence.

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Odds and market details are accurate as of the time of publication.